Located conveniently along the thriving economic I-85 corridor between Atlanta and Charlotte, USC Upstate is set in the picturesque foothills of the Blue Ridge Mountains. The 330-acre campus features modern facilities, sports venues, residential housing and green space.

John C. Stockwell Administration Building. The John C. Stockwell Administration Building was the first building built on campus and it opened in 1969. Positioned on top of the building is a shiny, gold-leaf dome that gleams in the sun and can be seen from afar.

The building houses the Chancellor’s Office, Academic Affairs, University Advancement, Institutional Effectiveness and Compliance, and University Marketing and Communications on the main floor. On the third floor are Human Resources, Business Services, Budget and Resource Planning, Purchasing Department, Professional Development, Sponsored Awards and Research Support, and Special Events. Information Technology and Services, and Institutional Planning and Research are located on the bottom floor.

The rear of the Administration Building features the Rose Terrace, an area overlooking the quadrangle where spring commencement is held each year.

G.B. Hodge Center. The G.B. Hodge Center is named for one of the University's founder Dr. G.B. Hodge. The Center was completed in 1973 and underwent renovations in 2000.

The Athletics Department is housed on the bottom floor and was renovated in 2010 and features all new seating, a new floor and a state-of-the-art Daktronics video scoreboard system and LED ProTables. Along with the renovations, the volleyball and basketball locker rooms are brand new with the addition of a new weight room, the Spartan Performance Center, and a state-of-the-art video control room.

The Hodge Center was nationally recognized in a study by Stadium Journey Magazine, as the publication ranked the arena the 15th-best Division I college basketball arena for game atmosphere and experience.

Media Building. The 44,000-square-foot Media Center building opened in 1978. It houses the Department of History, Political Science, Philosophy, and American Studies; the Department of Informatics and Engineering Systems; and the Department of Sociology, Criminal Justice and Women's and Gender Studies, the Center for Academic Innovation and Faculty Support, and the studios of WRET-TV, an affiliate of the South Carolina Educational Television Network, is also located here.

Burroughs Building. The Burroughs Building was built in 1976 and is named for William J. Burroughs, a founding member of the Spartanburg County Commission for Higher Education. It houses the Center for International Studies, the Center for African American Studies, and the South Carolina Centro Latino.

Arts and Science Building. Opened in 1982, the 26,066-square-foot Arts and Sciences Building houses the administrative offices for the College of Arts, Humanities, and Social Sciences, the College of Science and Technology, in addition to the Center for Interdisciplinary Studies, Department of Psychology, and the Center for Child Advocacy Studies.

This building originally housed the Mary Black College of Nursing (formerly the Mary Black School of Nursing), named for the late Mrs. Mary Louisa Snoddy Black, wife of Dr. Hugh Ratchford Black, who was a pioneer, innovator and leader in the field of medicine.

P. Kathryn Hicks Visual Arts Center. Renovated in 2003, the P. Kathryn Hicks Visual Arts Center is named for Katie Hicks, professor emerita and a generous benefactor to the univeristy, taught art at USC Upstate for more than 30 years.

The renovation of this building, nestled in the Susan Jacobs Arboretum, provides ample studio space for drawing, painting, graphic design, printmaking, digital imaging and three-dimensional design.

Humanities and Performing Arts Center. The Humanities and Performing Arts Center opened in 1990 this building features a 450-seat theater with a hydraulic pit lift, superb acoustics, the latest technology in theatre lighting, and a fully-rigged fly loft.

HPAC houses the Division of Fine Arts and Communication Studies (communications, theatre), Division of Languages, Literature & Composition, classrooms, a music recital hall, private practice rooms, art studios, the Curtis R. Harley Art gallery, FOCUS gallery and labs for digital design, writing, foreign language, and journalism.

Horace C. Smith Science Building. The Horace C. Smith Science Building opened in 1984 and underwent renovations in 2010 and 2021 to increase and improve laboratory spaces. The building houses the Division of Natural Sciences and Engineering. The second floor houses the division office, classrooms, biology, geology, and physics laboratories, and a NMR laboratory. The third floor houses classrooms, biology laboratories, faculty offices, and the USC Upstate Herbarium, which houses a research collection of mounted specimens of plants native to the Upstate. Chemistry facilities, including teaching and research laboratories, occupy the fourth floor, and there is also a large student computer lab and study area. The ground floor of Smith Building features a food court with indoor and outdoor seating.

Library. Constructed 1976, The Library originally opened with holdings totaling about 9,607. Today's facility, also designed for classrooms and office space, holds more than 220,000 volumes and boasts a fast-growing collection of important archives.

The Scholars Academy is housed on the second floor, along with the Student Success Center, and Career Management. On the lower level, with a separate entrance, is the Tukey Theater, a 140-seat lecture hall named for the late Richard E. Tukey, one of the community leaders instrumental in the establishment of USC Upstate.

Health Education Complex. The Health Education Complex is the first major academic building to be built in the northern segment of the campus. It is situated on top of a hill with panoramic views of the beautiful Susan Jacobs Arboretum and of the main campus. The Complex houses the Mary Black College of Nursing and the College of Education, Human Performance, and Health, the Enrollment Management Offices, the Bookstore, and the Spartan Recreation Center. The Spartan Recreation Center has an indoor track, basketball courts, racquet ball courts, a work-out room, a class studio, a swimming pool and locker rooms for both men and women.

John M. Rampey Center. Opened in 1992, the John M. Rampey Center's 6,200-square-foot facility houses Counseling and the Health Services satellite office.

Palmetto House. The $15 million, 105,000-square-foot Palmetto House Building opened in January 2004 provides housing for 346 upperclassmen.

Palmetto House offers suite-style housing with the most modern, gleaming amenities you can imagine. Each suite has a full bathroom, a communal living area with furniture, and a micro fridge (microwave and refrigerator combination). Each resident is also provided with a bed, a desk, two chests of drawers, and an armoire.

Palmetto House also offers all of the standard amenities, including basic electricity, water service and garbage collection. In addition, students receive cable hook-up, wireless Internet access, and stain and scratch resistant furniture.

Special features of Palmetto House include private study areas for in-house tutoring, free laundry facilities (including Laundry View, which allows a resident to determine the status of his/her laundry from their computer, and Laundry Text, which allows residents to receive a text message when their laundry is done), well-illuminated and gated parking lots, parking lot security cameras, emergency phones, and green space.

This co-educational facility features open areas, three recreation rooms, controlled access, full sprinkler system, computer lab, and adjacent parking. Additionally, this facility houses Sparty's Den which is also where postal services is located.

Magnolia House.  Magnolia House is a 105,000-square-foot traditional-style complex that can house up to 352 students in its 87 suites, including single or double rooms and handicap-accessible units. TRIO Student Support Services is in the ground floor of the Magnolia House.

The Magnolia House offers suite-style housing with the most modern, gleaming amenities you can imagine. Each suite has a full bathroom, a communal living area with furniture, and a micro fridge (microwave and refrigerator combination). Each resident is also provided with a bed, a desk, two chests of drawers, and an armoire.

Magnolia House also offers all of the standard amenities, including basic electricity, local phone services, water service, and garbage collection. In addition, students receive cable hook-up, wireless Internet access, and stain and scratch resistant furniture.

Special features of Magnolia House include eight study rooms for in-house tutoring, free laundry facilities (including Laundry View, which allows a resident to determine the status of his/her laundry from their computer, and Laundry Text, which allows residents to receive a text message when their laundry is done), well-illuminated and gated parking lots, parking lot security cameras, emergency phones, and green space.

Magnolia House offers the latest housing safety features available, such as controlled access, full sprinkler system, four levels of electronic locks to access bedrooms, and 32 monitored digital cameras inside and outside. It opened in fall 2009.

Palmetto Villas. The Villas offer more traditional-style apartments for upperclassmen. Each apartment has two bedrooms, two bathrooms, expanded cable outlets in each bedroom and living room, a full kitchen (full-size refrigerator, stove and microwave), sofa, loveseat, wi-fi and all utilities. The Villas also serve as living space for summer housing. The University obtained ownership of the Villas, a 12-building apartment complex in 1997.

University Readiness Center. Completed in 2003, the University Readiness Center is the result of a one-of-a-kind partnership between USC Upstate and the S.C. National Guard, which houses its high-end signal corps unit here while providing the University with additional classrooms, special events locations and support facilities for the Louis P. Howell Athletic Complex. The Exercise and Sports Science program, including a state of the art exercise science lab, is also located in the University Readiness Center.

Louis P. Howell Athletic Complex. The Louis P. Howell Athletic Complex includes the County University Soccer Stadium, Spartanburg County Youth Soccer Fields, Cleveland S. Harley Baseball Park, The Cyrill Softball Stadium, the Tennis Complex and the proposed site of a track and field facility. The Howell Complex attracts a greater number of students and the public to athletic events.

Cyrill Stadium. The Cyrill Stadium, named for University supporter Frank Cyrill, opened in 2002. The stadium features a playing field, dugouts, stadium seating and a press box. It has received numerous awards since its completion, the most recent being the 2015 College Softball Field of the Year by the Sports Turf Managers Association.

Harley Baseball Park. The Cleveland S. Harley Baseball Park opened for its first doubleheader on February 1, 2004 and features a playing field, dugouts, practice area, stadium seating, lights and a press box. The facility is named for one of the University’s founders who was a successful businessman and a strong supporter of education.

Soccer Stadium. The County University Soccer Stadium complex was officially completed with the opening of the University Readiness Center in May 2003. The building houses five locker rooms, a concession stand, hospitality suites, and public restrooms for the use of the men's and women's soccer programs. The Soccer Stadium has been the site of NCAA Tournament games in 2002 and 2003. In addition, the facility, along with the youth soccer fields, has hosted national and regional ODP camps as well as the Canadian Women's National Team. The facility earned the 2006 Sports Turf Managers College Soccer Field of the Year in South Carolina.

Intramural Field. The Intramural Field accommodates intramural sports, club sports, open recreation, and various special event activities.

Outdoor Recreational Facilities. A 1.3-mile passage of the Palmetto Trail begins at the Louis P. Howell Athletic Complex and leads into a wooded forest on the banks of the Lawson’s Fork Creek. Only hikers and bikers may use this section of the trail. Several other trails wind through the campus and more are currently under development. The USC Upstate Challenge Course seeks to give students the opportunity to sharpen interpersonal skills through the facilitation of various activities and groups.  Other recreation sites include intramural fields adjacent to the Palmetto House, five fields used primarily for recreational soccer located on the west side of the campus, and an 18 hole disc golf course located across the street from the Rampey Center.

Olin B. Sansbury, Jr. Campus Life Center. The Olin B. Sansbury, Jr. Campus Life Center is the hub of student life activity.

Opened in 1995, it houses Dining Services, Student Affairs, Counseling Services, Disability Services, student organization offices, student publication offices, several meeting rooms, a computer lab, an automated teller machine, and the Spartan Pantry. A large ballroom, overlooking the beautiful Susan Jacobs Arboretum, is often used for receptions and other events.

Roël Garden Pavilion. The Dr. Lawrence E. Roël Garden Pavilion is housed in the Susan Jacobs Arboretum and serves the campus as an outdoor classroom during the day with opportunities for recreational use in the evenings and on weekends.

Susan B. Jacobs Arboretum. The 12-acre arboretum, named for Susan B. Jacobs who is a graduate of The Mary Black School of Nursing at USC Upstate and a generous benefactor to the university, is located north of the Sansbury Campus Life Center along Persimmon Creek.  It features a 300-seat amphitheater, the Roël Pavilion, lighted walkways, and foliage indigenous to the area. The Arboretum serves as the center of gravity for campus life and student activities and provides a place for relaxation, for the enjoyment and advancement of academic studies, for contemplation and reflection, and for cultural, social and entertainment events.

Peace Park. The beautiful six-acre Upstate Rotary International Peace Park is a place to relax, contemplate, watch, wish and pray for peace and understanding. Dedicated in April 2008, future plans for the park include boardwalks, walking paths, a conifer collection, shrub roses and ornamental grasses.

Smith Farmhouse. The Smith Farmhouse is the oldest structure on the USC Upstate campus. Before this land was developed for USC Upstate, it was farmland and this house was used by the owners.

Today it has been totally renovated and is used to house the athletic offices for facilities, soccer, golf, cross country, and track and field. To accommodate the five Spartanburg County Youth Soccer Fields that are next to the Farmhouse, a wrap-around deck for vending concessions, walkways and exterior restrooms were added.

Health Services. Health Services offers health care and education to all enrolled students, faculty and staff on an outpatient basis. A nurse practitioner is available on a full-time basis by appointment.

A variety of informational health care flyers and brochures are available. In keeping with the university's metropolitan focus, Health Services strives to provide excellent health promotion programs, which emphasize coordination and interface with resources in the surrounding communities. It is located on University Way near Valley Falls Road with a satellite office in the John M. Rampey Center.

University Public Safety. The USC Upstate Public Safety Department strives to provide a safe, secure, and peaceful environment for students, staff, faculty, and visitors. It is located on North Campus Boulevard near Valley Falls Road.

Facilities Management. The facilities management building centralizes all components of facilities management (i.e., building maintenance, grounds maintenance, custodial services, capital planning, construction management, and administrative offices) into one facility, as opposed to several facilities scattered across the campus.

The University purchased and renovated a button and compressor building to create this 17,500 square foot maintenance, grounds and custodial center. In addition to the facility, 6.7 acres, contiguous with the north campus, were included in the purchase.

University Services Building and Postal Shipping and Receiving. The university services building houses our Watershed Ecology Center along with postal shipping and receiving. USC Upstate Postal Services Department operates within the department of Business Services, providing a full array of postal services including daily pick-up and delivery services of the U.S., inter-campus, and interagency mail to 1,000 residential students and over 700 faculty and staff personnel. Overnight and small package shipments and deliveries are handled through the U.S. Mail, FEDEX, and UPS.